LIVESTREAM RECORDING January 23, 2020
HMDHVC GRAND ROUNDS CONFERENCE
"Inflammation and Atherosclerosis: Where have we been? Where are we going?”
Houston Methodist DeBakey Heart & Vascular Center, Grand Rounds Conference featuring Paul M. Ridker, MD, as he discusses “Inflammation and Atherosclerosis: Where have we been? Where are we going?.
Introduction: William A. Zoghbi, MD
Speaker: Paul M. Ridker, MD
Presented by Houston Methodist DeBakey Heart & Vascular Center.
Paul M. Ridker, MD
Professor of Medicine, Director of the Center for Cardiovascular Disease Prevention
Brigham and Women's Hospital
Dr. Ridker serves as the Eugene Braunwald Professor of Medicine at the Harvard Medical School and directs the Center for Cardiovascular Disease Prevention, a population biology research unit at the Brigham and Women’s Hospital focused primarily on translating the biology of innate immunity and vascular inflammation into clinical practice. Best known for his pioneering work on inflammatory biomarkers such as high-sensitivity CRP and interleukin-6, the first demonstrations of the anti-inflammatory effects of statins, the guideline changing JUPITER trial in 2008, and ultimately through the CANTOS interleukin-1beta inhibition trial in 2017, Dr. Ridker's work has led to a fundamental shift in our understanding of atherosclerosis and to the first proof-of-principle that targeted anti-cytokine therapies can lower cardiovascular event rates in the absence of lipid lowering. Insights from his group that the magnitude of inflammation inhibition directly relates to the magnitude of clinical benefit has spawned a novel class of cardiovascular therapeutics, led to the clinical recognition that "residual inflammatory risk" is a separate and distinct entity from "residual cholesterol risk", and opened a novel approach to the treatment of inflammatory lung cancers.
This long-running lectureship was established in 1964 to honor James J. Truitt, M.D., a Houston internist and cardiologist and his wife, Una, under the aegis of the U.T. School of Public Health. In 1992, the name was changed to honor the distinguished career of William L. Winters, Jr., M.D., MACC MACP. Dr. Winters attended Princeton University, graduated from Northwestern Medical School and completed his training in general medicine and cardiology at Temple University Medical School in Philadelphia, Pennsylvania. There he served as Director of the Clinical Cardiovascular Research Center, General Medical Clinical Research Center, and Director of the Coronary Care Unit before moving to Houston in 1968. Dr. Winters remained in private practice with Don W. Chapman and the Houston Cardiovascular Associates and as Clinical Professor of Medicine at Baylor College of Medicine until 1994 when he joined the full-time faculty at Baylor as Professor of Medicine. He was Chief of the Section of International Medicine in the Department of Medicine (1998-2004) was elected Deputy Chair of the Department of Medicine (1995-1997) and Professor of Medicine at the Weill School of Medicine of Cornell University.
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HOUSTON METHODIST DEBAKEY HEART & VASCULAR CENTER
GRAND ROUNDS
STATEMENT OF NEED
This program is designed, in light of reviewing quality data retrieved from weekly evaluations, to provide physicians, faculty, fellows and residents access to topics in current basic and clinical research to improve patient care.
TARGET AUDIENCE
The target audience for this activity is: Cardiology and Cardiovascular Surgery Physicians, Fellows, Residents, NPs, PAs, Nurses, Radiologic Technologists, Sonographers and Research Coordinators.
EDUCATIONAL OBJECTIVES
At the conclusion of this activity, the participant should be able to:
• Discuss updates on diagnosis, treatment and management of cardiovascular disease.
• Integrate data and available technique in order to reach appropriate treatment decisions.
• Describe research models, methods and statistical tools.
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